Pregabalin: Dose-Response Relationship in Generalized Anxiety Disorder
نویسندگان
چکیده
منابع مشابه
Pregabalin in generalized anxiety disorder: a placebo-controlled trial.
OBJECTIVE Current drug therapies for generalized anxiety disorder have limitations. In a controlled trial, the novel agent pregabalin was studied for the treatment of patients with generalized anxiety disorder. METHOD In this double-blind study, patients with DSM-IV generalized anxiety disorder were randomly assigned to receive pregabalin (150 mg/day or 600 mg/day), lorazepam (6 mg/day), or p...
متن کاملGeneralized Anxiety Disorder in Adults: Focus on Pregabalin
Generalized anxiety disorder (GAD) is a chronic illness which impacts significantly on an individual’s functioning and quality of life. Pregabalin is a novel structural analogue of the inhibitory neurotransmitter GABA, acting to reduce calcium ion flow through the α2δ subunit of pre-synaptic voltage-dependent calcium channels. Pregabalin has been used in treatment of GAD in a total of eight pub...
متن کاملRole of pregabalin in the treatment of generalized anxiety disorder
Generalized anxiety disorder (GAD) is a common, typically persistent, and disabling condition that is often not recognised, or treated in an evidence-based manner. Current pharmacological and psychological treatment approaches have a number of drawbacks, including a delay in onset of clinical effect, varying relative efficacy against psychological or somatic symptoms of anxiety, potentially tro...
متن کاملpharmacotherapy Update: pregabalin in the Treatment of Generalized Anxiety Disorder
Generalized anxiety disorder (GAD) is a common disorder that is chronic, disabling, and often goes undiagnosed. Currently, four distinct classes of medications have demonstrated efficacy in the treatment of GAD: benzodiazepines, serotonin and/or norepinephrine reuptake inhibitors (SSRIs/SNRIs), histamine H1 receptor blockers (hydroxyzine), and pregabalin. Pregabalin acts via binding to an α2-δ ...
متن کاملPregabalin for the treatment of generalized anxiety disorder: an update
A PREVIOUS REVIEW SUMMARIZED WHAT WAS THEN KNOWN ABOUT THE POTENTIAL ROLE OF PREGABALIN IN THE TREATMENT OF PATIENTS WITH GENERALIZED ANXIETY DISORDER (GAD): this review provides an update on its pharmacological properties and presumed mechanism of action, the liability for abuse, and efficacy and tolerability in patients with GAD. Pregabalin has a similar molecular structure to the inhibitory ...
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ژورنال
عنوان ژورنال: Pharmacopsychiatry
سال: 2011
ISSN: 0176-3679,1439-0795
DOI: 10.1055/s-0031-1291176